\documentclass[border=5mm]{standalone}
\usepackage{pgfplots}
\usepackage[utf8]{inputenc}
\usepackage{amsmath}
\pgfplotstableread{
Century Manuscripts Books
6       13552           nan
7       10639           nan
8       43702           nan
9       201742  nan
10      135637  nan
11      212030  nan
12      768721  nan
13      1761951 nan
14      2746951 nan
15      4999161 12589000
16       nan            217444000
17      nan             531941000
18      nan             983874000
}\datatable
 
\definecolor{RYB1}{RGB}{128, 177, 211}
 
\begin{document}
\begin{tikzpicture}
  \begin{axis}[
        x=0.7895cm,
        axis on top=false, grid=both, xmajorgrids=false, xminorgrids=false, every minor grid/.style=gray!20,
        minor y tick num=3,
        axis lines*=left,
        width=12cm, height=8cm, enlarge x limits=0.25,
        ymin=0, ymax=1e9, scaled y ticks=false,
        yticklabel={\pgfmathprintnumber[fixed, set thousands separator=\,]{\tick}},
        enlarge y limits=false,
        ybar=-10pt, xtick={15,...,19}, xticklabel={\pgfmathparse{int(\tick)}\pgfmathresult.},
        xlabel=Jahrhundert, xlabel style={yshift=-1ex},ylabel=Anzahl der\\Exemplare,
         ylabel style={rotate=-90, align=left, anchor=east, xshift=-5ex, name=ylabel},
        title={Europäische Produktion von gedruckten Büchern ca. 1450--1800$^{\text{\tiny{*}}}$},
        title style={font=\large\bfseries, align=center,yshift=1ex}
        ]
 
\addplot +[fill=RYB1, draw=RYB1!50!black] table [y=Books] {\datatable};
\draw (rel axis cs:0,0) -- (rel axis cs:1,0);                 
  \end{axis}
\node at (current axis.below south) [anchor=north, align=left, font=\tiny] {$^*$ohne Südosteuropa (osmanischer Bereich) und Russland};
 
\end{tikzpicture}
\end{document}